• In summary we have established

  2019-06-15

  

  In summary, we have established an animal model of human NB bone metastasis in which COX-2/PGE2 plays a critical role. We provide pre-clinical data supporting the use of COX-2 inhibitors in the treatment of bone metastases in NB. Conflict of interest statement Introduction Desmoplastic fibrom

• FD appears radiographically as radiolucent areas

  2019-06-15

  

  FD appears radiographically as radiolucent areas which later develop into a partially opaque ground glass appearance [51]. Other features that may be present are endosteal scalloping, bony expansion, and a thick reactive bone ‘rind’ [54]. MR imaging may be a more effective tool at identifying the si

• Performing an ajmaline test in

  2019-06-15

  

  Performing an ajmaline test in children is problematic for 2 reasons. First, the test is apparently less sensitive in children than in adults. In fact, in 1 study, a repeat ajmaline challenge performed after puberty unmasked BrS in 23% of relatives with a previously negative drug test performed duri

• Las formas transmisibles no del saber o de la

  2019-06-15

  

  “Las formas transmisibles, no del saber o de la sabiduría de un hombre, sino sobre todo su vida vivida —y esa es la materia con que se hacen historias— sólo son adquiridas al morir”, afirma Walter Benjamin. La muerte atraviesa toda la Historia verdadera: como motivo, como temor, como asombro o recue

• As Canadians queue to vote in the federal election

  2019-06-15

  

  As Canadians queue to vote in the federal election next week, some will be uncomfortable knowing that the new Fair Elections Act that requires an official photo identification will overwhelmingly discriminate against those who are least likely to produce it—the very groups cited by UNCOHR. Many Cana

• Resulta importante resaltar el surgimiento de nuevos patrone

  2019-06-14

  

  Resulta importante resaltar el surgimiento de nuevos patrones de lectura e interpretación de los escenarios políticos en Latinoamérica, porque ello explica su desplazamiento en los modos de leer que hasta 1960 habían caracterizado sus ensayos. Estos descubrimientos propiciados por la Revolución pusi

• br Sebastian Vollmer and colleagues April conclude

  2019-06-14

  

  Sebastian Vollmer and colleagues (April, 2014) conclude that “the contribution of economic growth to the diazoxide manufacturer in early childhood undernutrition in developing countries is very small, if it exists at all”. Progress will therefore require a shift from “the so-called trickle-down a

• auda Analyses such as those used by Burke and

  2019-06-14

  

  Analyses such as those used by Burke and colleagues rely on periodic cross-sectional surveys that are not linked to available or civic registration and vital statistics databases. These surveys are also limited by the inevitable time lag between analyses and feedback to health systems and policy mak

• pikfyve inhibitor br Authors disclosure Mark Clemons receive

  2019-06-14

  

  Authors\' disclosure Mark Clemons received honoraria for talks from Novartis and Amgen, research funding from Novartis. Case In September 2007 a 9½-year-old boy was diagnosed with a Ewing sarcoma (EWS-FL1 translocation positive) of the right scapula. MRI showed a tumor of 8.0×2.9 ×6.2cm locat

• The medical environment in Asian

  2019-06-14

  

  The medical environment in Asian-Pacific countries is widely different from that in Western countries in terms of disease prevalence, CIED implant rates, and other parameters. Moreover, there are remarkable differences in the manner patients are followed-up among the countries in the Asian-Pacific r

• When compared with lidocaine both amiodarone

  2019-06-14

  

  When compared with lidocaine, both amiodarone and nifekalant were proved similarly effective for ventricular arrhythmias suppression. These drugs, however, have characteristic adverse effects, such as negative inotropic and chronotropic outcomes (amiodarone), and QT prolongation resulting in torsade

• Antenatal corticosteroids induce fetal lung

  2019-06-14

  

  Antenatal corticosteroids induce fetal lung maturation through the same biological mechanism in low-income settings as in high-income settings and reduce the need for neonatal mechanical ventilation. Although antenatal corticosteroids might not be a so-called magic bullet as a standalone vertical in

• br The introduction of direct

  2019-06-14

  

  The introduction of direct-acting antiviral drugs (DAAs) is changing the treatment options for hepatitis C oxycodone hydrochloride (HCV). These new medicines were initially marketed at a very high price, but several countries have negotiated favourable price reductions, and, in view of the low co

• Recently emerging data suggest that lower frequency

  2019-06-13

  

  Recently emerging data suggest that lower frequency of IV bisphosphonates in metastatic breast cancer has the same efficacy as monthly regimen [48]. ONJ on the other hand can be extremely symptomatic with a severely detrimental effect on quality of life. A case-control study based on risk factors f

• Self reported health SRH is considered

  2019-06-13

  

  Self-reported health (SRH) is considered to be a valuable source of data on various aspects of general health. In fact, it is one of the most widely used indicators of health status in survey research, and is recommended by the World Health Organization. SRH can be influenced by individual determina

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