• In this issue of EBioMedicine Enroth and colleagues present

  2018-11-05

  

  In this issue of EBioMedicine, Enroth and colleagues () present a comprehensive study that analyzes the individual contribution of factors related to the collection and long-term sample storage in a highly homogenous group of Northern European subjects (). Taking advantage of the sampling strategy o

• There are caveats with the above mentioned studies First

  2018-11-05

  

  There are caveats with the above mentioned studies. First, there is no good method for accurately quantifying autophagy in vivo, and especially in human patients. This makes it difficult to be sure that drugs that increase autophagic flux in cultured nk1 antagonist are also doing so in vivo. Second

• br Limitations and future lines of investigation

  2018-11-05

  

  Limitations and future lines of investigation This exploratory study has a series of limitations. First, the use of a sample of university students from a specific school can affect the external validity of the results. Second, we studied parental influence in only one region of Spain. Thus, a co

• Narcolepsy may be mono symptomatic only ES or

  2018-11-05

  

  Narcolepsy may be mono-symptomatic (only ES) or oligo-symptomatic (ES and cataplexy). The degree of ES is variable and the attacks of cataplexy might involve several muscle groups being triggered by emotions [1,3]. The use of modafinil in the treatment of narcolepsy is a first option for the treatm

• The availability of energy resources likely affects the

  2018-11-05

  

  The availability of energy resources likely affects the body’s ability to expend effort. One means by which energy is released is through glucose metabolism. Glucose utilization as reflected by plasma glucose levels was reduced during the 24h sleep deprivation period and was associated with decrease

• Daytime somnolence was assessed by

  2018-11-05

  

  Daytime somnolence was assessed by the use of the Epworth sleepiness scale, which consists of eight questions rated on a four point Likert scale ranging from 0 (no chance of falling asleep) to 3 (high chance of falling asleep) with a maximum total score of 24; a score ≥10 is considered positive [11]

• br Conclusion Key contributions of this study are the sugges

  2018-11-05

  

  Conclusion Key contributions of this study are the suggestion that one week of antibiotic treatment is insufficient to effect important changes in the gut ecosystem in most CFS participants, that reducing the levels of gram-positive gut microbiota is associated with some improvement in objective

• Two experienced sleep scorers one board certified evaluated

  2018-11-05

  

  Two experienced sleep scorers (one board certified) evaluated seven hours of recording. The recording contained 6h and 45min of sleep preceded by 15min of wakefulness. Both scorers analysed first the standard EEG liver x receptor then repeated the process looking exclusively at the intra-ear and in

• The literature shows scarce efforts made for

  2018-11-05

  

  The literature shows scarce efforts made for the development of diagnostic tools and devices with potential for effective monitoring of chronic wounds. Matzeu et al. [14] demonstrated an RFID-based skin temperature monitoring system obtaining a 0.2°C temperature measurement accuracy. A flexible plat

• br Conclusion br Conflict of interest

  2018-11-05

  

  Conclusion Conflict of interest Acknowledgements Introduction Basophils, resident in blood, and mast cells, resident in connective and mucosal tissues, have important roles in type I allergy or IgE-associated diseases, such as food allergy, hay fever, and atopic dermatitis (AD). The bind

• dabigatran etexilate br Experimental section br Results and

  2018-11-05

  

  Experimental section Results and discussion Conclusions In summary, we have prepared a kind of N-doped polymer-like nanoparticles from non-conjugated natural products, tartaric dabigatran etexilate and citric acid. This method has some advantages such as easy-to-enlarge, easy-to-operate, h

• El papel de organismos econ micos financieros y de

  2018-11-03

  

  El papel de organismos económicos, financieros y de cooperación internacional, en la promoción del uso de tic en los últimos 15 años, ha sido de la mayor relevancia, tanto desde el punto de vista teórico, al apoyar la visión de que un uso mayor de tic tiene incidencia sobre la competitividad y el cr

• For the samples sintered from the nanometric micrometric

  2018-11-03

  

  For the samples sintered from the 40% nanometric – 60% micrometric powders, with both compaction procedures, the elastic limit is within the 500–530MPa range. The direct-SPS sample presents a sharper strain hardening, especially in the beginning of the plastic deformation, for a maximum stress of 73

• br Experimental design materials and methods br

  2018-11-03

  

  Experimental design, materials and methods Acknowledgements We acknowledge Aveleda S.A. for supplying the wine used in this study and to SAI Lda for providing the activated carbons. We appreciate the financial support provided to the Research Unit in Vila Real (PEst-OE/QUI/UI0616/2014) by Fund

• br Data The data represent the observation

  2018-11-03

  

  Data The data represent the observation from experiments of tissue microarray, Western blot and flow cytometry. Data in Table 1 are the list of sequences of siRNA, shRNA, miRNA and PCR primer used in a related research article [1]. The data of the association of CMPK protein expression with clini

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