• All these claims led to the paradoxical situation whereby

  2018-10-26

  

  All these claims led to the paradoxical situation whereby the heart, previously described as a non-renewing organ, has turned into the organ with the highest number of distinct types of resident stem/progenitor cells. However, aside from the Isl-1pos cardiac progenitor cells, which are direct progen

• Recently several studies have suggested

  2018-10-26

  

  Recently, several studies have suggested that peripheral blood mononuclear Spadin (PBMCs) are a promising resource for generating iPSCs because most of these cells do not undergo TCR rearrangement (Loh et al., 2010; Mack et al., 2011; Seki et al., 2010). However, PBMCs are composed of several cell t

• Recently we found that vesicular monoamine transporter VMAT

  2018-10-26

  

  Recently, we found that vesicular monoamine transporter 2 (VMAT2) regulates monoamine (including dopamine) storage by acting as a negative regulator, such that high monoamine levels inhibit the progression from Pdx1+ pancreatic progenitor gaboxadol to Neurog3+ endocrine progenitor cells of ESC-deri

• Introduction Cellular phenotypes are characterized by stable

  2018-10-26

  

  Introduction Cellular phenotypes are characterized by stable gene-expression states determined by underlying gene-regulatory networks (GRNs), particularly by subnetworks that appear frequently and are functionally important (i.e., GRN motifs). A classical GRN motif, the toggle switch, constitutes a

• br Results br Discussion Here we present a method to

  2018-10-26

  

  Results Discussion Here, we present a method to induce a pluripotent-like state even in tumor mtor inhibitors with a high mutational load. Melanoma cells harboring BRAF or NRAS mutations were amenable to reprogramming similarly to wild-type cells. In contrast to the “classical” reprogramming p

• It is important for sorption enhanced

  2018-10-26

  

  It is important for sorption-enhanced catalytic processes occurring in an aqueous medium that the MnО2 phase be in a hydrated state. This requirement imposes certain restrictions on the conditions in which this phase can be synthesized, particularly on the CL surface that is sensitive to acidic and

• Regarding our controls there is empirical support for our fi

  2018-10-26

  

  Regarding our controls, there is empirical support for our findings associated with the marriage growth rate in several micro studies (Gunnell, Middleton, Whitley, Dorling, & Frankel, 2003; Kposowa, 2000). These scholars claim that suicide rates are lower for married than for unmarried persons, and

• Specificity is also valuable in terms of operationalization

  2018-10-26

  

  Specificity is also valuable in terms of operationalization of variables and the conceputalisation of salient environmental correlates in different contexts and population groups. In a sample of 190 older adults in the USA, univariate analyses demonstrated a significant association between physical

• In order to analyze and illustrate Table

  2018-10-26

  

  In order to analyze and illustrate (Table 1, Figs. 2–3) steepness of changes in the EEG indexes during transitions from one stage to another, one-min values were further averaged on 3-min intervals (i.e., from minute −4 to −2, from −1 to +1, from +2 to +4, etc.). Additionally, all positive and negat

• br Insomnia symptoms etiology and manifestations We consider

  2018-10-26

  

  Insomnia – symptoms, etiology, and manifestations We consider that although insomnia is called a “sleep disorder”, it is actually a “waking disorder”, in which the waking system is overactive, intruding excessively into sleep time. Perhaps in treating insomnia, we should not be trying to increase

• akt inhibitor Laboratory studies have shown that total sleep

  2018-10-26

  

  Laboratory studies have shown that total sleep deprivation for 24–72h impairs the performance of many tasks [1,6,7]. So, it is possible that the lack of sleep may affect a basic cognitive process, such as attention, working memory or executive functions, crucial for the execution of a broad range o

• In the present data the prevalence of the morning

  2018-10-26

  

  In the present data, the prevalence of the morning type was low (N=47, 8.9%). The proportion of the intermediate type was the highest (N=298, 54.5%), followed by evening type (N=194, 35.0%). The genders were equally represented in the chronotypes, Pearson χ2(2)=1.79, n.s. The results of the analysi

• br Limitations and strengths There are several limitations t

  2018-10-26

  

  Limitations and strengths There are several limitations to our study. First, sleep-related problems were subjectively measured; therefore, some misclassifications might have occurred. Nonetheless, questions about self-reported sleep problems for timing and duration have demonstrated good validity

• The sensing element in a biosensor usually combines

  2018-10-26

  

  The sensing element in a biosensor usually combines an electrochemical probe with an appropriate enzyme thin layer [15,16]. In triglycerides (TG) biosensors [17–19], a usual choice for the enzyme is lipase since its chemical action is to catalyze the hydrolysis of triacylglycerol to glycerol and fa

• In the first test the chip

  2018-10-26

  

  In the first test, the chip was covered with csf1r and thermally ablated once. Then it was thermally ablated again in increments, and resonant frequencies were measured in between increments. Small frequency shifts were measured (~2kHz) for the third mode, with diminishing shifts as the number of i

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