During development extrinsic signals in a progenitor s

2018-10-20

During development, extrinsic signals in a progenitor’s microenvironment provide cues for self-renewal and lineage commitment. Although several growth factors, including fibroblast growth factors (FGFs) 2 (Perantoni et al., 1995), 8 (Perantoni et al., 2005), 9, and 20 (Barak et al., 2012) and epider

br Results br Discussion A

2018-10-20

Results Discussion A series of studies has reported that TBX3 was indispensable for maintenance of pluripotency. In line, TBX3 gain of function facilitated induction of pluripotency (Han et al., 2010a; Ivanova et al., 2006; Lee et al., 2012; Lu et al., 2011; Nishiyama et al., 2013) but interes

The Gata site regulates a large

2018-10-20

The Gata2 +9.5 site regulates a large gene cohort in hemogenic endothelium, and these genes do not parse into a single pathway (Gao et al., 2013). The genes include Runx1, Lyl1, and Mpl, positive mediators of HSC generation and/or function. The identification of vital constituents of the +9.5-depend

px12 Introduction MicroRNAs miRNAs are small non coding

2018-10-20

Introduction MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate the stability and translation of protein-coding transcripts through partial complementarity with their 3′ UTRs (Jaskiewicz and Filipowicz, 2008). There have been reports that miRNAs affect histone modifications or D

Primary tissue or hiPSC derived VSMCs have been previously

2018-10-20

Primary tissue- or hiPSC-derived VSMCs have been previously used to establish vascular tissue constructs with different scaffold materials, such as polyglycolic acid, fibrin, and poly-L-lactic histone deacetylase inhibitors (Bajpai et al., 2012; Niklason et al., 1999; Sundaram et al., 2014; Wang et 

Alzheimer s disease AD is the most common

2018-10-20

Alzheimer\'s disease (AD) is the most common neurodegenerative disorder. The pathological hallmarks of AD include extracellular amyloid plaques consisting mainly of Aβ42, and intracellular neurofibrillary tangles comprising mainly hyperphosphorylated tau (Serrano-Pozo et al., 2011). Previous studies

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2018-07-29