• br The Case for Systemic Administration of Oncolytic

  2018-11-05

  

  The Case for Systemic Administration of Oncolytic Viruses While Imlygic and several other OV platforms are designed as loco-regional therapeutics, for a variety of reasons, intravenous administration ultimately may be the preferred route of delivery (Naik et al., 2012). Metastatic or widespread c

• Disclosure br High grade serous ovarian cancer

  2018-11-05

  

  Disclosure High-grade serous ovarian cancer (HGSOC) has a high mortality rate because the disease is asymptomatic in early stages and is resistant to treatments. A novel modality for diagnosis in the early stages of carcinogenesis is needed. In this issue of , Hellner et al. present novel genetic

• Polyubiquitylation leading to proteolytic degradation

  2018-11-05

  

  Polyubiquitylation leading to proteolytic degradation by the 26S proteasome is involved in all aspects of cell physiology. The highly coordinated process ensures the selective and timely turnover of proteins, thereby controlling cellular activity and maintaining cell and tissue homeostasis (Glickman

• In Fig countries are ranked by the percentage of normalized

  2018-11-05

  

  In Fig. 1, countries are ranked by the percentage of (normalized) negative sentiment expressed towards a given question. (All figures quoted are normalized responses.) Respondents from Bangladesh (0.3%), Ecuador (0.4%), and Iran (0.5%) report the lowest levels of importance-related skepticism, whils

• In Fig countries are ranked by the percentage of normalized

  2018-11-05

  

  In Fig. 1, countries are ranked by the percentage of (normalized) negative sentiment expressed towards a given question. (All figures quoted are normalized responses.) Respondents from Bangladesh (0.3%), Ecuador (0.4%), and Iran (0.5%) report the lowest levels of importance-related skepticism, whils

• Remarkably Cornelius et al report for the first

  2018-11-05

  

  Remarkably, Cornelius et al. report for the first time HBV-neutralizing antibodies in all seven so-far tested human recipients of the BM32 vaccine, i.e., of preS antigen without other HBV antigens. Assay of neutralizing antibodies has been difficult because for long time the only HBV-susceptible cel

• In Fig countries are ranked by the percentage of normalized

  2018-11-05

  

  In Fig. 1, countries are ranked by the percentage of (normalized) negative sentiment expressed towards a given question. (All figures quoted are normalized responses.) Respondents from Bangladesh (0.3%), Ecuador (0.4%), and Iran (0.5%) report the lowest levels of importance-related skepticism, whils

• In this issue of EBioMedicine Enroth and colleagues present

  2018-11-05

  

  In this issue of EBioMedicine, Enroth and colleagues () present a comprehensive study that analyzes the individual contribution of factors related to the collection and long-term sample storage in a highly homogenous group of Northern European subjects (). Taking advantage of the sampling strategy o

• There are caveats with the above mentioned studies First

  2018-11-05

  

  There are caveats with the above mentioned studies. First, there is no good method for accurately quantifying autophagy in vivo, and especially in human patients. This makes it difficult to be sure that drugs that increase autophagic flux in cultured nk1 antagonist are also doing so in vivo. Second

• br Limitations and future lines of investigation

  2018-11-05

  

  Limitations and future lines of investigation This exploratory study has a series of limitations. First, the use of a sample of university students from a specific school can affect the external validity of the results. Second, we studied parental influence in only one region of Spain. Thus, a co

• Narcolepsy may be mono symptomatic only ES or

  2018-11-05

  

  Narcolepsy may be mono-symptomatic (only ES) or oligo-symptomatic (ES and cataplexy). The degree of ES is variable and the attacks of cataplexy might involve several muscle groups being triggered by emotions [1,3]. The use of modafinil in the treatment of narcolepsy is a first option for the treatm

• The availability of energy resources likely affects the

  2018-11-05

  

  The availability of energy resources likely affects the body’s ability to expend effort. One means by which energy is released is through glucose metabolism. Glucose utilization as reflected by plasma glucose levels was reduced during the 24h sleep deprivation period and was associated with decrease

• Daytime somnolence was assessed by

  2018-11-05

  

  Daytime somnolence was assessed by the use of the Epworth sleepiness scale, which consists of eight questions rated on a four point Likert scale ranging from 0 (no chance of falling asleep) to 3 (high chance of falling asleep) with a maximum total score of 24; a score ≥10 is considered positive [11]

• br Conclusion Key contributions of this study are the sugges

  2018-11-05

  

  Conclusion Key contributions of this study are the suggestion that one week of antibiotic treatment is insufficient to effect important changes in the gut ecosystem in most CFS participants, that reducing the levels of gram-positive gut microbiota is associated with some improvement in objective

• Two experienced sleep scorers one board certified evaluated

  2018-11-05

  

  Two experienced sleep scorers (one board certified) evaluated seven hours of recording. The recording contained 6h and 45min of sleep preceded by 15min of wakefulness. Both scorers analysed first the standard EEG liver x receptor then repeated the process looking exclusively at the intra-ear and in

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