• br Genetic rescue of GluR A dependent spatial

  2021-12-09

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific 20 hydroxyecdysone synthesis of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt

• In the liver ghrelin has

  2021-12-09

  

  In the liver, ghrelin has opposite effects to insulin on the expression of the enzyme PEPCK, thereby promoting gluconeogenesis and also causing a decrease in glucose uptake and fatty phospholipase a2 inhibitor oxidation (Rigault et al., 2007). Ghrelin also stimulates hepatic lipogenesis de novo in

• br Therapeutic approaches exploiting Cx function Due to thei

  2021-12-09

  

  Therapeutic approaches exploiting Cx43 function Due to their potential role in cancer metastasis, attempts have been made to alter connexin function to inhibit cancer growth. Therapeutic approaches include Cx43 peptide mimetics, Cx43 inhibitors, chemical agents capable of enhancing Cx43 function,

• br Presenilins in protein trafficking proteolysis and degrad

  2021-12-09

  

  Presenilins in protein trafficking, proteolysis and degradation An obvious explanation for the role of presenilins and γ-secretase in protein trafficking and degradation is that many reported γ-secretase substrates are functionally involved in protein transport. For example, members of the mammal

• Somatostatin analogues are among the first peptide based dru

  2021-12-09

  

  Somatostatin analogues are among the first peptide-based drugs used in cancer imaging and therapy (for review see Reubi, 2003). Treatment of tumors by the use of peptide analogues labeled with cytotoxic agents acting via specific receptors is also under investigation for neuropeptide Y (Koglin and

• The ultimate success of multimodal probe

  2021-12-09

  

  The ultimate success of multimodal probe in the inflammation imaging will be dependent on simplicity in synthesis (combining various modules without protection/deprotection), ease of optimization of pharmacological properties (linker group with tunable PEG moiety), co-registration of macroscopic and

• LDN 57444 In the current study we report the properties of P

  2021-12-09

  

  In the current study, we report the properties of P. anserina mutants carrying mutations in a gene encoding the bi-functional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2). This enzyme catalyzes two opposite reactions (Pilkis et al., 1995, Rider et al., 2004): synthesi

• It is well known that TNF

  2021-12-09

  

  It is well known that TNF-α plays a pivotal role in the pathogenesis of RA. TNF-α influences diverse pathologic processes including joint destruction as well as inflammatory responses [16]. While TNF-α significantly increases the levels of sFas and mFas expression from FLS, IL-1β and IL-17 have mini

• Axitinib mg br Materials and methods br Results br Discussio

  2021-12-09

  

  Materials and methods Results Discussion Protein degradation plays a vital role in nearly all cellular processes, nearly 5% of genes are dedicated to the control of protein stability [31], [32]. The ubiquitin-proteasome system (UPS) represents the major way for degradation of proteins, wher

• Considering their good FAAH inhibitory activity compounds an

  2021-12-09

  

  Considering their good FAAH inhibitory activity, compounds and have been selected for an in vivo study in a DSS-induced colitis model. Specific Pathogen Free male 7weeks old C57/Bl6 mice received 2.5% DSS in drinking water during 8days. Concomitantly, they were administrated daily intraperitoneall

• br Introduction Stroke is the second cause of death worldwid

  2021-12-09

  

  Introduction Stroke is the second cause of death worldwide and the first cause of acquired motor disability in adults [1], [2]. In sub-Saharan Africa, stroke is the first cause of admission in neurology departments [3]. In Cameroon, the in-hospital mortality of stroke is estimated at 26.8% [4]. A

• The importance of the histone chaperone

  2021-12-09

  

  The importance of the histone chaperone function of Hat1p was highlighted by the recent demonstration that the catalytic activity of Hat1p is not sufficient for its function in vivo. Fusion of a nuclear export signal (NES) to yeast Hat1p effectively excluded the enzyme from the nucleus, with a conco

• br Introduction The role of histamine in allergic

  2021-12-09

  

  Introduction The role of histamine in allergic responses, anaphylaxis, and gastric Lonafarnib receptor secretion has been well described in both human and veterinary medicine. New roles for histamine and its receptors, however, have been elucidated over the last two decades (Smuda and Bryce, 201

• The haspin gene is also unusual

  2021-12-08

  

  The haspin gene is also unusual because it lacks introns. This is more remarkable when one compares the mammalian genes to those of likely haspin orthologs that are present in the genomic sequences of other species. Such genes in Drosophilamelagonaster, Arabidopsisthaliana and Caenorhabditiselegans

• The biological activity at GPR a of

  2021-12-08

  

  The biological activity at GPR109a of each of the 4-functionalized-5-alkyl-pyrazole-3-carboxylic acids (–) was measured using a cAMP whole cell Dynamic2 Homogenous Time-Resolved Fluorescence (HTRF) assay (). Twelve compounds were found to exhibit an EC below 1μM, and of these seven exhibited EC valu

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