• GPR belongs to the G protein coupled receptor

  2021-10-12

  

  GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty RepSox (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in bone marrow, spl

• br Introduction Cell surface receptors

  2021-10-12

  

  Introduction Cell surface receptors are central to the interaction of cells with their surroundings and play an important role in determining functional responses. These receptors are integral membrane proteins responsible for the binding of extracellular signaling molecules and transduction into

• The soluble receptor for advanced glycation end products

  2021-10-12

  

  The soluble receptor for advanced glycation end products has been already studied in physiological and pathological pregnancy. In accordance to our previous studies we showed increased sRAGE serum levels in women with threatening premature labor [15] and we described a negative correlation of sRAGE

• Kern et al observed an

  2021-10-12

  

  Kern et al observed an overall improvement in behaviors typical for autism during TR. They used the Childhood Autism Rating Score (CARS), to determine the intensity of the change and found lower CARS values after 3 (t(21) = 2.73, p but sodium fluoride comparison of differences in QoL improvement in

• The EEGs of these six patients interestingly

  2021-10-12

  

  The EEGs of these six patients interestingly showed focal, multi-focal and generalized spikes, which was an exclusion criteria in our study as we selected our cohort to exclusively represent focal epilepsy. Remarkably all of these cases were diagnosed with paroxysmal exercise-induced dyskinesia (PED

• br Glucocorticoid receptor and metabolic syndrome GCs acting

  2021-10-11

  

  Glucocorticoid receptor and metabolic syndrome GCs acting through the GR regulate key enzymes of glucose metabolism in the liver, skeletal muscle, adipose tissue and the pancreas. In the liver, GCs regulate the expression of major gluconeogenic enzymes such as phosphoenolpyruvate carboxykinase, g

• br Materials and Methods br Results br Discussion

  2021-10-11

  

  Materials and Methods Results Discussion In the present study, we investigated the postnatal expression of the two GABA receptor subunits, GABAAα1 and GABAB1, in order to determine the differential expression and regional distribution pattern of them between right and left hippocampi in the

• At this point it needs however

  2021-10-11

  

  At this point it needs, however, to be mentioned that most in vivo studies regarding the herein discussed nuclear receptors were performed in rodents, especially in mice. Due to the significant differences in metabolism in mice and humans, not all results are translatable between these species and h

• br Introduction For decades regulated

  2021-10-11

  

  Introduction For decades, regulated apoptosis and unregulated, accidental necrosis have been considered as the two sole cell death routes in multicellular organisms. With the beginning of the 21st century a paradigm shift has been witnessed by researchers in the field with the recognition that ma

• OS has a key role

  2021-10-11

  

  OS has a key role in the pathogenesis of micro- and macrovascular diabetic complications [3]. There is now convincing evidence that the enzymes that generate ROS and gasotransmitters, such as nitric oxide (NO) and CO, are redox regulated at both the transcription and activity levels, and are also im

• HBV is an enveloped double stranded DNA virus which

  2021-10-11

  

  HBV is an enveloped, double-stranded DNA virus, which is transcripted into four major transcripts [6]. Among them, the 3.5 kb pregenomic RNA (pgRNA) directs the translation of HBV polymerase, core protein and acts as template for reverse transcription. So viral transcription is a key step of virus l

• Alzheimer s disease AD is

  2021-10-11

  

  Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the presence of abnormal filamentous protein inclusions in nerve cells of the brain [2]. The neuropathological hallmarks of AD were first reported by Alois Alzheimer and date back to 1907 [3], [4]. These inclusions are for

• Niacin nicotinic acid is widely used to regulate abnormaliti

  2021-10-11

  

  Niacin (nicotinic acid) is widely used to regulate abnormalities in plasma lipid and lipoprotein metabolism, as evidenced by its potential for reducing atherosclerotic cardiovascular disease risks (Guyton, 1998), due to its ability to reduce circulating triglycerides and apolipoprotein-B containing

• phospholipase a2 inhibitor Currently ursodeoxycholic acid UD

  2021-10-11

  

  Currently, ursodeoxycholic phospholipase a2 inhibitor (UDCA) is the only recommended and widely used drug in the treatment of CFLD. However, the clinical efficacy of UDCA is controversial. The most recent Cochrane review only identified a small number of trials assessing the effectiveness of UDCA [

• cl 2 The results of our study indicate

  2021-10-11

  

  The results of our study indicate the general importance of the gp120 V3 loop cl 2 patch in the subunit association of primate immunodeficiency virus Env trimers. Our observation that the stem insertion mutants and hydrophobic patch mutants exhibit similar phenotypes with respect to gp120 shedding

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