• Materials and methods br Results Assay of botulinum

  2021-07-15

  

  Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases. The frequently encountered active forms of the toxin are; L chain (inside intoxicated neuronal cells), BoNT (in the blood stream of a botulism patient,

• Oxysterols modulate the immune responses and

  2021-07-15

  

  Oxysterols modulate the immune responses and as such could be effectors of the tumor environment: 25-OHC impairs IgA production in B-lymphocytes [26] and induces the secretion of the proinflammatory and angiogenic cytokine IL-8 [27], [28]. Of note, oxysterols (in particular 7α,25-OHC) are potent che

• E ubiquitin ligases are key

  2021-07-15

  

  E3 ubiquitin ligases are key players in the ubiquitin-proteasome pathway because they catalyse ubiquitination of substrate proteins.39, 40, 41 As important regulators of cellular ubiquitination, E3 ligases are emerging as attractive drug targets, particularly in cancer.42, 43, 44 However, E3 ligases

• In the past few years neuroprotection via GLP R

  2021-07-15

  

  In the past few years, neuroprotection via GLP-1R activation has been shown in several animal models of stroke, Alzheimer's, Parkinson's, Huntington's, ALS and traumatic 4-ap injury. This research field is rapidly growing and several reviews have been recently published (Darsalia et al., 2014b, Folt

• br Effect of DPP Inhibitors on the Clinical Course

  2021-07-15

  

  Effect of DPP-4 Inhibitors on the Clinical Course of Heart Failure Four large-scale cardiovascular outcomes trials with DPP-4 inhibitors have been completed, and their findings have been published (Table 1) 31, 32, 33, 34. In 2 studies (with saxagliptin and alogliptin), DPP-4 inhibition was accom

• br Experiments and Methods br

  2021-07-15

  

  Experiments and Methods Results and Discussion Conclusions Here, the interactions between two newly-synthesized carbazole derivative—cationic δ,δ′‑diazacarbazoles and DNA were characterized by several spectroscopic means, including UV–Vis and fluorescence, AFM and fluorescence imaging. The

• Diacylglycerol kinase was one of

  2021-07-15

  

  Diacylglycerol kinase was one of the hits identified from the RNAi screen. Diacylglycerol kinases are conserved across a TAPI-1 of species with more complex, multicellular organisms possessing several DGKs with differing protein domains, expression patterns and functions [61], [62], [63]. Some of t

• ApicomplexansApicomplexans are unicellular and spore

  2021-07-15

  

  ApicomplexansApicomplexans are unicellular and spore-forming obligate intracellular parasites that occupy diverse host niches (Mogi and Kita 2010). They have remodeled mitochondrial carbon and energy metabolism through reductive evolution. The development of novel drugs is now a very serious challen

• Nivolumab Among the other mediators which have

  2021-07-14

  

  Among the other mediators which have been reported to play a role in erection are prostaglandins (PGs). Several studies have reported that alprostadil- synthetic PGE1- showed high efficacy in management of erectile dysfunction as it induces corpus cavernosal relaxation. Alprostadil has been first de

• Assessment of DNA damage by comet assay and ChEs activity

  2021-07-14

  

  Assessment of DNA damage by comet assay and ChEs activity has been widely used as a biomarker of genotoxicity and exposure to pesticide respectively, to measure the risk related to pesticides in the exposed population [15]. Very few studies have explored the association between DNA damage and worker

• Kshirsagar et al previously reported an association between

  2021-07-14

  

  Kshirsagar et al. previously reported an association between CHK2thr68 expression and the presence of the chromatin remodeling factor Rsf-1 in solid HGSC specimens [22]. Rsf-1 expression was previously analyzed in our effusion series and was found to be related to poor survival [23]. Analysis of the

• Our previous high throughput screening HTS

  2021-07-14

  

  Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based bimatoprost australia assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20], [21

• lxr agonist br Materials and methods br

  2021-07-14

  

  Materials and methods Results Discussion PKA and Epac are two principal effector proteins involved in cAMP signaling; they are expressed in a wide range of tissues and control diverse biological functions [10]. The existence of two cAMP effectors provides more precise regulation of cAMP sig

• Given the molecular pharmacology and in vitro

  2021-07-14

  

  Given the molecular pharmacology and in vitro metabolism data, we proceeded to evaluate the in vivo pharmacokinetics of . Mice (=3) were subsequently administered a subcutaneous dose (5mg/kg) with intermittent plasma collections to measure systemic levels of (). Compound achieved a maximum plasma

• Furan analogs and N methylpyrrole analogs had completely dif

  2021-07-14

  

  Furan analogs and N-methylpyrrole analogs had completely different SARs. For example, replacement of the furan-2-sulfonyl moiety of 6 with the furan-3-sulfonyl moiety resulted in 8 with a decreased EP1 GSK2656157 affinity and an increased antagonist activity, while the corresponding chemical modific

15552 records 580/1037 page Previous Next First page 上5页 576577578579580 下5页 Last page