• While resistance to imatinib is rare in patients

  2019-07-01

  

  While resistance to imatinib is rare in patients treated in CML-CP, resistance does eventually develop in the majority of patients treated in the advanced phases. In a high proportion of patients who develop secondary resistance after initial responses, point mutations in the BCR-ABL kinase domain h

• fluvastatin sodium br Discussion Chronic myelogenous leukemi

  2019-07-01

  

  Discussion Chronic myelogenous leukemia (CML) is a clonal disorder involving the pluripotent stem cell and is consistently associated with the BCR-ABL1 fusion gene located on the Philadelphia chromosome [1]. The disease typically evolves in 3 distinct clinical stages: chronic and accelerated pha

• Findings Baseline data were collected

  2019-06-29

  

  Findings Baseline data were collected between Sept 6, 2011, and Nov 11, 2012. Between January, 2013, and September, 2014, 62 midwives completed triage training and we collected post-training triage data from Dec 12, 2014, to January 24, 2015. In 2014, compliance of use and correctness of wristbandin

• Introduction The Space Shuttle has been retired and the

  2019-06-29

  

  Introduction The Space Shuttle has been retired and the International Space Station (ISS) will be in use until 2020 (Fig. 1). Scientists and engineers are thinking about a mission to Mars in the future. Human exploration of space is at a turning point, and a number of questions about the future of

• The OptiVol Fluid Index OVFI which is derived

  2019-06-29

  

  The OptiVol Fluid Index (OVFI), which is derived from changes in intrathoracic impedance, can effectively assess HF by analyzing the changes in the intrathoracic impedance detected by the original OptiVol algorithm. Small et al. previously determined that a frequent and extended threshold crossing S

• Introduction Brugada syndrome is severe arrhythmia character

  2019-06-29

  

  Introduction Brugada syndrome is severe arrhythmia characterized by specific ST elevations in precordial leads and sudden ventricular fibrillation (VF), and the condition may result in sudden cardiac death [1–5]. By implanting defibrillation devices, also known as implantable cardioverter-defibrill

• In our case the LV

  2019-06-29

  

  In our case, the LV-triggered pace algorithm had 2 modes: “RVs” and “RVs+RVEs”. In the “RVs” mode, LV pacing synchronizes with RV-sensed events. It aims to maintain the CRT benefits even if intrinsic AV conduction shortens with an increase in sympathetic nerve activity. In the “RVs+RVEs” mode, LV p

• br Discussion Unfortunately it was not possible

  2019-06-29

  

  Discussion Unfortunately it was not possible to perfom a RCT comparing medical ozone gas therapy in respect to standard therapy because all our 24 patients had been previously treated with various cycles of antibiotic therapies before we could start the therapy with O3 gas. Moreover the patients

• br Materials and methods br

  2019-06-29

  

  Materials and methods Results Discussion The present study has demonstrated that the Wavelet discrimination algorithm is affected by myopotential interference, as evidenced by the large number of patients (55%) showing positive morphology change (defined as the percent-match score of the Wa

• In the American College of Chest Physicians

  2019-06-29

  

  In 2013, the American College of Chest Physicians provided a guideline to the preoperative physiological assessment of patients being considered for surgical resection of lung cancer. It has been recommended that patients must be assessed by a multidisciplinary team before operation, regardless of a

• The benign exostoses in TRPS have a recognized malignant pot

  2019-06-29

  

  The benign exostoses in TRPS have a recognized malignant potential which have been shown to develop into chondrosarcomas [4,13]. Both our index case and his mother demonstrated de novo high grade osteosarcoma. To our knowledge, this occurrence has not been described anywhere within the literature.

• br Introduction Multiple signal transduction pathways in nor

  2019-06-29

  

  Introduction Multiple signal transduction pathways in normal and malignant Fidaxomicin converge on Bcl-2 family proteins, which stand at the crossroads between cell survival and apoptosis. The seminal event in the intrinsic pathway of apoptosis is mitochondrial outer membrane permeabilization (MO

• br The influx of refugees

  2019-06-29

  

  The influx of refugees has placed tremendous strains on existing health-care facilities in Syria neighbouring countries like Jordan. Jordan\'s ceramide has swelled by 20% since the inception of the Syrian civil war. The response from the WHO has been splintered and timid, even in comparison with t

• Subsequently more detailed mapping was performed to

  2019-06-29

  

  Subsequently, more detailed mapping was performed to identify the Purkinje potential preceding the QRS onset of the PVCs in their region of origin (Fig. 2B). Radiofrequency ablation was performed at the site of the earliest Purkinje potential preceding the local ventricular potential (Fig. 2C and D)

• br Short case report A year old man with persistent

  2019-06-28

  

  Short case report A 65-year-old man with persistent AF underwent multi-detector computed tomography (CT) before catheter ablation. An anomalous muscular band connecting the posterior side of the left atrial roof and the right edge of fossa ovalis in the left atrium was detected (Fig. 1). During

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